Artificial Chromosomes

BACs Bacterial Artificial Chromosomes,

i) use fertility F plasmid

ii) 75-300 kb inserts possible

iii) Developed during the humane genome project

YACs Yeast Artificial Chromosomes

i) Mimics Yeast chromosome

ii) Contains all regions for replication (Yeast Ori and centromere)

iii) Produced during the human genome progect

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