Mendelian Genetics Archive

Interaction of Genes

Genes act by controlling cellular chemistry. Early in the twentieth century, Archibald Garrod, an English physician, made the first observation supporting this insight. Garrod noted that several recessive human diseases show defects in what is called metabolism, the general set of chemical …

Human Pedigree Analysis

Human matings, like those of experimental organisms, provide many examples of single-gene inheritance. However, controlled experimental crosses cannot be made with humans, and so geneticists must resort to scrutinizing medical records in the hope that informative matings have been made (such …

Autosomal inheritance in humans

Human matings, like those of experimental organisms, show many examples of the inheritance patterns described above. Because controlled experimental crosses cannot be made with humans, geneticists must resort to scrutinizing records in the hope that informative matings have been made …

Mendel’s law segregation

Mendel’s model for the pea-color example, translated into modern terms, was as follows 1. A hereditary factor called a gene is necessary for producing pea color. 2. Each plant has a pair of this type of gene. 3. The gene comes …

Single Gene Inheritance

The genetic approach to understanding any biological property is to find the subset of genes in the genome that influence that property, a process sometimes referred to as gene discovery. After these genes have been identified, their cellular functions can be elucidated …

Mendel’s pioneering work

The first-ever analysis of single-gene inheritance as a pathway to gene discovery was carried out by Gregor Mendel. His is the analysis that we shall follow as an example. Mendel chose the garden pea, Pisum sativum, as his research organism.The choice of …